Product image is illustrative. Your medication and packaging may look different.
No. 10 · Skin
GHK-Cu 2% Copper Peptide Cream
Topical copper peptide, 2%
GHK-Cu is a copper-binding peptide found naturally in the body, and lab research shows it supports collagen and skin repair. RULE Longevity offers a compounded 2% GHK-Cu cream, $229 a month, after a licensed provider review; it is not FDA-approved, and human studies of topical use are small.
| Option | Monthly | Start |
|---|---|---|
| GHK-Cu 2% cream, 30 g | $229per month | Start |
- Online visit and licensed provider review
- Medication and supplies, if prescribed
- Shipping in discreet packaging
- Messaging with your care team
- Cancel anytime before your next billing date
If you are not prescribed, no medication ships and no subscription starts. Questions first? Use our contact form.
Who it's for
- Adults who want an evidence-informed addition to a skincare routine
- People who find retinoids hard to tolerate
- Skin that has changed with age or sun
Not for
- A known copper allergy or allergy to an ingredient
- Broken, infected or freshly treated skin, unless your provider says otherwise
- Pregnancy or breastfeeding, where there is not enough data
Your licensed provider reviews your full history and decides what is appropriate.
How it works
Answer a short skin and health questionnaire online
A licensed provider reviews it and decides whether GHK-Cu cream is appropriate
Your cream ships from a licensed US pharmacy
Apply as directed, with daily sunscreen
What's included
- Online visit and licensed provider review
- Compounded GHK-Cu 2% cream, 30 g
- Discreet shipping
- Messaging with your care team
Important safety information
- Stop using it and contact your care team if you develop redness, stinging, itching, swelling or a rash.
- Patch test on a small area first if your skin is reactive.
- For external use only. Avoid eyes and mucous membranes.
- Compounded medications are prepared by a licensed US pharmacy for an individual patient. They are not FDA-approved, and the FDA does not verify their safety, effectiveness or quality before they are dispensed.
Prescription only. A licensed provider reviews your health history in an online visit and decides whether this program is appropriate for you. Tell your provider about every medication, supplement, allergy and condition, and whether you are pregnant, trying to conceive or breastfeeding. If you have a severe reaction, trouble breathing, chest pain or swelling of the face or throat, call 911.
Full details: safety information. Updated October 28, 2026.
What is GHK-Cu copper peptide cream?
GHK-Cu is a copper peptide found naturally in the body, and RULE Longevity offers it as a compounded 2% topical cream. It is not FDA-approved. It is $229 per month for a 30 g jar when a provider decides it is appropriate.
Does copper peptide cream work for wrinkles?
Lab studies and small human studies suggest GHK-Cu may support skin firmness and texture, but the evidence is limited. Results vary from person to person. Your provider can help you set realistic goals.
Is GHK-Cu cream FDA-approved?
No. Compounded GHK-Cu 2% cream is not FDA-approved. It is prepared by a licensed pharmacy for an individual patient with a prescription.
Why does GHK-Cu 2% cream need a prescription?
The 2% cream from RULE Longevity is a compounded medication, so a licensed provider must review your visit and prescribe it. That review checks your skin history, allergies and other products you use. It is a topical cream only.
Sources
- Pickart L, Margolina A, Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data, 2018
- Pickart L et al., GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration, 2015
- FDA, Compounding and the FDA: Questions and Answers
Reviewed October 28, 2026.
Ready to start?
A licensed provider reviews your online visit and decides whether GHK-Cu Cream is right for you.