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No. 02 · Weight
Tirzepatide Weight Program
Weekly dual GIP and GLP-1 injection
Tirzepatide is a weekly injection that acts on two hormone pathways, GIP and GLP-1, that help regulate appetite and blood sugar. RULE Longevity offers compounded tirzepatide, from $299 a month, after a licensed provider review; compounded tirzepatide is not FDA-approved, and results vary.
| Option | Monthly | Start |
|---|---|---|
| Tirzepatide, starting dosesHigher-dose pricing is shown in your online visit | From $299per month | Start |
- Online visit and licensed provider review
- Medication and supplies, if prescribed
- Shipping in discreet packaging
- Messaging with your care team
- Cancel anytime before your next billing date
If you are not prescribed, no medication ships and no subscription starts. Questions first? Use our contact form.
Who it's for
- Adults with a BMI of 30 or more, or 27 or more with a weight-related condition
- People who want a licensed provider to compare tirzepatide and semaglutide for them
- People committed to protein, resistance training and follow-up check-ins
Not for
- A personal or family history of medullary thyroid cancer or MEN 2
- Pregnancy, trying to conceive or breastfeeding
- A history of pancreatitis, unless your provider approves
- Type 1 diabetes
Your licensed provider reviews your full history and decides what is appropriate.
How it works
Complete the online weight visit
A licensed provider reviews your history and decides whether tirzepatide is appropriate
If prescribed, medication and supplies ship from a licensed US pharmacy
Your provider steps the dose up at check-ins as needed
Semaglutide vs tirzepatide, side by side
| Semaglutide | Tirzepatide | |
|---|---|---|
| How it works | GLP-1 receptor | GIP and GLP-1 receptors |
| How often | Once a week | Once a week |
| Form | Injection under the skin | Injection under the skin |
| RULE version | Compounded (not FDA-approved) | Compounded (not FDA-approved) |
| RULE price | From $199 a month | From $299 a month |
Format comparison only, not a comparison of results. A licensed provider decides which, if either, is right for you.
What's included
- Online visit and licensed provider review
- Compounded tirzepatide with B12 or glycine, plus supplies
- Discreet, temperature-protected shipping
- Dose check-ins and messaging with your care team
Important safety information
- Nausea, diarrhea, vomiting, constipation and reduced appetite are common, mostly as the dose increases.
- Brand tirzepatide carries a boxed warning about thyroid C-cell tumors seen in rodents. Do not use it if you or your family have had medullary thyroid cancer or MEN 2.
- Get care right away for severe ongoing stomach pain, gallbladder symptoms, signs of dehydration or an allergic reaction.
- Tirzepatide can make birth control pills less effective after starting and after each dose increase. Ask your provider about a backup method.
- Brand tirzepatide (Zepbound, Mounjaro) is FDA-approved. The FDA ended the tirzepatide shortage in December 2024 and has raised concerns about compounded versions.
- Compounded medications are prepared by a licensed US pharmacy for an individual patient. They are not FDA-approved, and the FDA does not verify their safety, effectiveness or quality before they are dispensed.
Prescription only. A licensed provider reviews your health history in an online visit and decides whether this program is appropriate for you. Tell your provider about every medication, supplement, allergy and condition, and whether you are pregnant, trying to conceive or breastfeeding. If you have a severe reaction, trouble breathing, chest pain or swelling of the face or throat, call 911.
Full details: safety information. Updated October 28, 2026.
Is compounded tirzepatide the same as Zepbound or Mounjaro?
No. Zepbound and Mounjaro are FDA-approved brand tirzepatide products. Compounded tirzepatide is prepared by a licensed pharmacy, often with B12 or glycine, and is not FDA-approved. Your provider decides which option is appropriate.
Is tirzepatide stronger than semaglutide?
Tirzepatide acts on two hormone pathways (GIP and GLP-1), while semaglutide acts on one (GLP-1). Some studies show more average weight loss with tirzepatide, but individual results vary. Your provider decides which medication fits your health history and goals.
How much does tirzepatide cost per month?
The RULE Longevity Tirzepatide Weight Program starts at $299 per month, with shipping included. Higher-dose price tiers are still being set, and your provider sets your dose.
Who qualifies for tirzepatide?
Your provider decides based on your weight, health history, current medications and goals. Tirzepatide is generally not appropriate for people with a personal or family history of medullary thyroid cancer or MEN 2, or who are pregnant. Complete the online visit to find out whether it is right for you.
Can I switch from semaglutide to tirzepatide?
Yes, a switch is possible if your provider decides it is appropriate. Tell your provider what you take now, how long you have taken it and any side effects, and they will set your new dose. Do not switch or combine medications on your own.
Sources
- FDA label via DailyMed, Zepbound (tirzepatide) prescribing information
- MedlinePlus, Tirzepatide Injection
- FDA, FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss
- FDA, FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize
- NIDDK, Prescription Medications to Treat Overweight and Obesity
Reviewed October 28, 2026.
Read more
Health GuideGLP-1 Side Effects: What to Expect and When to Call
Most GLP-1 side effects are digestive and ease with time. Learn what is common, how protein and hydration help, and which warning signs from the semaglutide and tirzepatide labels need prompt care.
WeightIs Compounded Semaglutide FDA-Approved? What Changed in 2025
Compounded semaglutide is not FDA-approved. Learn how it differs from brand Wegovy and Ozempic, what the end of the FDA shortage changed for pharmacies, and how to check that a pharmacy is licensed.
WeightSemaglutide vs Tirzepatide: How the Two Weight Programs Differ
Semaglutide acts on one gut hormone receptor (GLP-1) and tirzepatide acts on two (GIP and GLP-1). Here is how the two weight programs compare on how they work, side effects, safety and cost.
Ready to start?
A licensed provider reviews your online visit and decides whether Tirzepatide is right for you.