Product image is illustrative. Your medication and packaging may look different.
No. 07 · Men's Health
Tadalafil
As needed or daily, for ED
Tadalafil is an FDA-approved PDE5 inhibitor for erectile dysfunction, sold as a generic of Cialis, and it works for up to about 36 hours after a dose. RULE Longevity offers tadalafil from $129 a month after a licensed provider review, as needed or as a daily low dose.
| Option | Monthly | Start |
|---|---|---|
| Tadalafil tablets | $129per month | Start |
- Online visit and licensed provider review
- Medication and supplies, if prescribed
- Shipping in discreet packaging
- Messaging with your care team
- Cancel anytime before your next billing date
If you are not prescribed, no medication ships and no subscription starts. Questions first? Use our contact form.
Who it's for
- Men with erectile dysfunction
- Men who want a longer window than sildenafil
- Men who prefer a daily low dose, if their provider agrees
Not for
- Anyone who takes nitrates (such as nitroglycerin) or riociguat
- Men told to avoid sexual activity for heart reasons
- Severe liver or kidney disease, unless your provider approves
Your licensed provider reviews your full history and decides what is appropriate.
How it works
Complete a private online visit, including heart history and medicines
A licensed provider decides whether tadalafil is appropriate and which form
Tablets ship in discreet packaging
Message your care team with questions anytime
Tadalafil vs sildenafil, side by side
| Tadalafil | Sildenafil | |
|---|---|---|
| Works for | Up to about 36 hours | About 4 hours |
| How you take it | As needed, or a daily low dose | As needed, about an hour before |
| Food | Not affected much by food | A heavy meal can slow it |
| Generic of | Cialis | Viagra |
| Never with | Nitrates or riociguat | Nitrates or riociguat |
| RULE price | $129 a month | $129 a month |
Format comparison only, not a comparison of results. A licensed provider decides which, if either, is right for you.
What's included
- Online visit and licensed provider review
- Generic tadalafil tablets
- Discreet shipping
- Messaging with your care team
Important safety information
- Common effects include headache, indigestion, back pain, muscle aches, flushing and a stuffy nose.
- Never take it with nitrates or riociguat: the combination can drop blood pressure dangerously.
- Get emergency care for an erection lasting more than 4 hours, sudden vision loss or sudden hearing loss.
- Alpha blockers and large amounts of alcohol can add to blood pressure drops.
Prescription only. A licensed provider reviews your health history in an online visit and decides whether this program is appropriate for you. Tell your provider about every medication, supplement, allergy and condition, and whether you are pregnant, trying to conceive or breastfeeding. If you have a severe reaction, trouble breathing, chest pain or swelling of the face or throat, call 911.
Full details: safety information. Updated October 28, 2026.
Is generic tadalafil the same as Cialis?
Yes. Generic tadalafil contains the same active ingredient as Cialis, which is FDA-approved for erectile dysfunction. Generic versions must meet FDA standards for quality and performance.
Can I take tadalafil every day?
Tadalafil can be prescribed as a daily option or as needed, and your provider decides which fits you and sets the dose. Daily use is meant to keep a steady level so timing is less of a concern. Take it exactly as your provider and the label direct.
Who should not take tadalafil?
Never take tadalafil with nitrates, such as nitroglycerin, because the combination can drop blood pressure dangerously. It may also not be right for people with certain heart conditions or who take alpha blockers or riociguat. Your provider reviews your medications and health history first.
How much is tadalafil online?
The RULE Longevity Tadalafil program is $129 per month, with shipping included and discreet packaging. A licensed provider reviews your online visit before prescribing.
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Ready to start?
A licensed provider reviews your online visit and decides whether Tadalafil is right for you.