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No. 01 · Weight
Semaglutide Weight Program
Weekly GLP-1 injection
Semaglutide is a GLP-1 medicine that works on appetite and fullness signals, given as a weekly injection. RULE Longevity offers compounded semaglutide, from $199 a month, after a licensed provider reviews your online visit; compounded semaglutide is not FDA-approved, and results vary.
| Option | Monthly | Start |
|---|---|---|
| Semaglutide, starting dosesHigher-dose pricing is shown in your online visit | From $199per month | Start |
- Online visit and licensed provider review
- Medication and supplies, if prescribed
- Shipping in discreet packaging
- Messaging with your care team
- Cancel anytime before your next billing date
If you are not prescribed, no medication ships and no subscription starts. Questions first? Use our contact form.
Who it's for
- Adults with a BMI of 30 or more, or 27 or more with a weight-related condition such as high blood pressure
- People ready to pair medication with protein, strength training and sleep
- People who want a licensed provider to set and adjust the dose
Not for
- A personal or family history of medullary thyroid cancer or MEN 2
- Pregnancy, trying to conceive or breastfeeding
- A history of pancreatitis, unless your provider approves
- Type 1 diabetes
Your licensed provider reviews your full history and decides what is appropriate.
How it works
Answer a secure health and weight questionnaire online
A licensed provider reviews it and decides whether semaglutide is appropriate
If prescribed, your medication and supplies ship from a licensed US pharmacy
Your provider adjusts the dose at check-ins, step by step
Semaglutide vs tirzepatide, side by side
| Semaglutide | Tirzepatide | |
|---|---|---|
| How it works | GLP-1 receptor | GIP and GLP-1 receptors |
| How often | Once a week | Once a week |
| Form | Injection under the skin | Injection under the skin |
| RULE version | Compounded (not FDA-approved) | Compounded (not FDA-approved) |
| RULE price | From $199 a month | From $299 a month |
Format comparison only, not a comparison of results. A licensed provider decides which, if either, is right for you.
What's included
- Online visit and licensed provider review
- Compounded semaglutide with B12 or glycine, plus supplies
- Shipping in discreet, temperature-protected packaging
- Dose check-ins and messaging with your care team
Important safety information
- The most common effects are nausea, vomiting, diarrhea, constipation and stomach pain, especially when the dose goes up.
- Brand semaglutide carries a boxed warning about thyroid C-cell tumors seen in rodents. Do not use it if you or your family have had medullary thyroid cancer or MEN 2.
- Get care right away for severe stomach pain that does not go away (possible pancreatitis), pain in the upper right belly or yellow skin (possible gallbladder problems), or signs of an allergic reaction.
- Low blood sugar is more likely if you also take insulin or a sulfonylurea. Tell your provider about every diabetes medicine.
- Brand semaglutide (Wegovy, Ozempic) is FDA-approved. The FDA declared the semaglutide shortage over in February 2025 and has raised concerns about compounded versions.
- Compounded medications are prepared by a licensed US pharmacy for an individual patient. They are not FDA-approved, and the FDA does not verify their safety, effectiveness or quality before they are dispensed.
Prescription only. A licensed provider reviews your health history in an online visit and decides whether this program is appropriate for you. Tell your provider about every medication, supplement, allergy and condition, and whether you are pregnant, trying to conceive or breastfeeding. If you have a severe reaction, trouble breathing, chest pain or swelling of the face or throat, call 911.
Full details: safety information. Updated October 28, 2026.
Is compounded semaglutide FDA-approved?
No. Compounded semaglutide is not FDA-approved. Brand semaglutide, sold as Wegovy and Ozempic, is FDA-approved. A licensed provider decides whether a compounded version is appropriate for you.
Can you still get compounded semaglutide now that the shortage is over?
Yes, in limited cases. The FDA declared the semaglutide shortage over in February 2025, which limits compounding. A licensed 503A pharmacy may still compound it for an individual patient with a documented clinical need, and your provider decides whether that applies to you.
What is the difference between compounded semaglutide and Ozempic or Wegovy?
Ozempic and Wegovy are FDA-approved brand products made by the manufacturer. Compounded semaglutide is prepared by a licensed pharmacy, often with B12 or glycine, and is not FDA-approved. Your provider can explain which option fits your health history.
How much is semaglutide per month in Miami?
The RULE Longevity Semaglutide Weight Program starts at $199 per month, with shipping included. Higher-dose price tiers are still being set, and your provider sets your dose. Your exact price is shown before you pay.
What are the common side effects of semaglutide?
The most common side effects are stomach related, such as nausea, vomiting, diarrhea and constipation. Serious risks listed for semaglutide include pancreatitis, gallbladder problems and a boxed warning about thyroid tumors. Your provider reviews your history and tells you what to watch for.
Sources
- FDA label via DailyMed, Wegovy (semaglutide) prescribing information
- MedlinePlus, Semaglutide Injection
- FDA, FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss
- FDA, FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize
- NIDDK, Prescription Medications to Treat Overweight and Obesity
Reviewed October 28, 2026.
Read more
Health GuideGLP-1 Side Effects: What to Expect and When to Call
Most GLP-1 side effects are digestive and ease with time. Learn what is common, how protein and hydration help, and which warning signs from the semaglutide and tirzepatide labels need prompt care.
WeightIs Compounded Semaglutide FDA-Approved? What Changed in 2025
Compounded semaglutide is not FDA-approved. Learn how it differs from brand Wegovy and Ozempic, what the end of the FDA shortage changed for pharmacies, and how to check that a pharmacy is licensed.
WeightSemaglutide vs Tirzepatide: How the Two Weight Programs Differ
Semaglutide acts on one gut hormone receptor (GLP-1) and tirzepatide acts on two (GIP and GLP-1). Here is how the two weight programs compare on how they work, side effects, safety and cost.
Ready to start?
A licensed provider reviews your online visit and decides whether Semaglutide is right for you.