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No. 06 · Sexual Wellness
PT-141
Bremelanotide, for women and men
PT-141 is the research name for bremelanotide, a medicine that acts on brain pathways tied to sexual desire rather than on blood flow. Brand bremelanotide (Vyleesi) is FDA-approved only for premenopausal women with acquired, generalized low sexual desire; use in men and the compounded version RULE Longevity offers are not FDA-approved.
| Option | Monthly | Start |
|---|---|---|
| PT-141 for women | $249per month | Start |
| PT-141 for menUse in men is off-label | $249per month | Start |
- Online visit and licensed provider review
- Medication and supplies, if prescribed
- Shipping in discreet packaging
- Messaging with your care team
- Cancel anytime before your next billing date
If you are not prescribed, no medication ships and no subscription starts. Questions first? Use our contact form.
Who it's for
- Premenopausal women with low desire that is persistent and distressing
- Men whose provider judges it appropriate, understanding use in men is off-label
- People whose provider has reviewed other causes, such as medicines and stress
Not for
- Uncontrolled high blood pressure or known heart disease
- Pregnancy
- Anyone taking oral naltrexone without provider review
Your licensed provider reviews your full history and decides what is appropriate.
How it works
Complete a private online visit
A licensed provider reviews your history and blood pressure
If prescribed, it ships in discreet packaging
Follow your label exactly, including how often you may use it
What's included
- Online visit and licensed provider review
- Compounded PT-141 injection
- Supplies and discreet shipping
- Messaging with your care team
Important safety information
- Nausea is the most common side effect; in the brand product's trials about 40% of women had nausea.
- It can raise blood pressure and lower heart rate for several hours after a dose.
- Darkening of the gums and skin on the face or breasts has been reported and may not fully fade.
- Injections go under the skin with a small needle, following the written directions that come with your prescription. Redness, stinging or a small bump where you inject are common. Never share or reuse needles, and use a sharps container.
- Compounded medications are prepared by a licensed US pharmacy for an individual patient. They are not FDA-approved, and the FDA does not verify their safety, effectiveness or quality before they are dispensed.
Prescription only. A licensed provider reviews your health history in an online visit and decides whether this program is appropriate for you. Tell your provider about every medication, supplement, allergy and condition, and whether you are pregnant, trying to conceive or breastfeeding. If you have a severe reaction, trouble breathing, chest pain or swelling of the face or throat, call 911.
Full details: safety information. Updated October 28, 2026.
What is PT-141?
PT-141 is bremelanotide, a peptide that acts on the brain pathways involved in sexual desire rather than on blood flow. Brand bremelanotide (Vyleesi) is FDA-approved only for premenopausal women with acquired, generalized hypoactive sexual desire disorder. RULE Longevity offers compounded PT-141 for women or men, which is not FDA-approved.
Does PT-141 work for men?
PT-141 has been studied in men in small trials, but use in men is off-label and it is not FDA-approved for men. Some men use it for desire and arousal, and results vary. Your provider decides whether it fits your health history.
How is PT-141 different from Viagra?
Viagra (sildenafil) increases blood flow, while PT-141 acts on desire pathways in the brain. Viagra is FDA-approved for erectile dysfunction, and compounded PT-141 is not FDA-approved. Your provider can explain which, if either, fits your goals.
What are the side effects of PT-141?
The most common side effects are nausea, flushing, headache and injection site reactions. It can also cause a temporary rise in blood pressure, so it is not right for everyone with heart disease or uncontrolled blood pressure. Your provider reviews your history first.
How much does PT-141 cost?
The RULE Longevity PT-141 program is $249 per month, with shipping included. A licensed provider must review your online visit and decide that it is appropriate first.
Sources
- FDA label via DailyMed, Vyleesi (bremelanotide injection) prescribing information
- MedlinePlus, Bremelanotide Injection
- Diamond LE et al., Double-blind, placebo-controlled evaluation of intranasal PT-141 in healthy males and men with mild to moderate erectile dysfunction, 2004
- FDA, Compounding and the FDA: Questions and Answers
Reviewed October 28, 2026.
Ready to start?
A licensed provider reviews your online visit and decides whether PT-141 is right for you.