Product image is illustrative. Your medication and packaging may look different.
No. 03 · Performance and Recovery
Sermorelin
Growth hormone releasing peptide
Sermorelin is a lab-made version of the first 29 amino acids of growth hormone releasing hormone, and it prompts the pituitary to release your own growth hormone. A brand version was once FDA-approved and later discontinued by its maker for business reasons; the compounded sermorelin RULE Longevity offers is not FDA-approved, and evidence for wellness or anti-aging use is limited.
| Option | Monthly | Start |
|---|---|---|
| Sermorelin injection | $249per month | Start |
- Online visit and licensed provider review
- Medication and supplies, if prescribed
- Shipping in discreet packaging
- Messaging with your care team
- Cancel anytime before your next billing date
If you are not prescribed, no medication ships and no subscription starts. Questions first? Use our contact form.
Who it's for
- Active adults interested in sleep, recovery and body composition support who accept that evidence is limited
- People comfortable with small injections under the skin
Not for
- Active cancer or a history of cancer unless your provider approves
- Pregnancy or breastfeeding
- Anyone under 18
- Untreated thyroid problems
Your licensed provider reviews your full history and decides what is appropriate.
How it works
Complete the online visit
A licensed provider reviews your history and decides whether sermorelin is appropriate
If prescribed, it ships from a licensed US pharmacy with supplies
Inject as directed on your label and check in with your care team
What's included
- Online visit and licensed provider review
- Compounded sermorelin injection (3 mg/mL, 5 mL)
- Supplies and shipping
- Messaging with your care team
Important safety information
- Common effects include redness, swelling or pain where you inject, flushing, headache and trouble sleeping.
- Injections go under the skin with a small needle, following the written directions that come with your prescription. Redness, stinging or a small bump where you inject are common. Never share or reuse needles, and use a sharps container.
- Growth hormone affects blood sugar and other hormones, so your provider may ask about diabetes, thyroid conditions and medicines first.
- Sermorelin may be prohibited in tested sport. Check your sport's anti-doping rules before starting.
- Compounded medications are prepared by a licensed US pharmacy for an individual patient. They are not FDA-approved, and the FDA does not verify their safety, effectiveness or quality before they are dispensed.
Prescription only. A licensed provider reviews your health history in an online visit and decides whether this program is appropriate for you. Tell your provider about every medication, supplement, allergy and condition, and whether you are pregnant, trying to conceive or breastfeeding. If you have a severe reaction, trouble breathing, chest pain or swelling of the face or throat, call 911.
Full details: safety information. Updated October 28, 2026.
What is sermorelin?
Sermorelin is a peptide that is an analog of growth hormone releasing hormone, which signals your pituitary gland to release its own growth hormone. RULE Longevity offers compounded sermorelin injection at $249 per month, and a provider decides whether it fits you.
Is sermorelin FDA-approved?
Compounded sermorelin is not FDA-approved. A brand version was once FDA-approved and was later discontinued by its maker for business reasons. Today sermorelin is available only through a prescription filled by a licensed compounding pharmacy.
What is the difference between sermorelin and HGH?
HGH is growth hormone itself, while sermorelin prompts your body to release its own growth hormone. They are different medications with different rules and risks. Your provider can explain which, if either, is appropriate for you.
Does sermorelin work for anti-aging?
The evidence for sermorelin in wellness or anti-aging use is limited. Some people use it for sleep, recovery or body composition goals, but results vary and are not proven for those uses. Your provider reviews your goals and health history before deciding.
Sources
- Federal Register, Determination That Geref (sermorelin acetate) Was Not Withdrawn From Sale for Reasons of Safety or Effectiveness (2013)
- Walker RF, Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging 2006
- Khorram O et al., Endocrine and metabolic effects of long-term administration of a GHRH-(1-29) analog in age-advanced men and women, 1997
- FDA, Compounding and the FDA: Questions and Answers
Reviewed October 28, 2026.
Ready to start?
A licensed provider reviews your online visit and decides whether Sermorelin is right for you.